检索临床试验

REACT-AF是一项多中心前瞻性研究, 随机, 非盲, 盲法终点(PROBE设计), controlled trial comparing the current Standard Of Care (SOC) of continuous Direct Oral Anticoagulation (DOAC) use versus time-delimited (1 month) DOAC guided by an AF-sensing Smart Watch (AFSW) in participants with a history of paroxysmal or persistent Atrial Fibrillation (AF) and low-to-moderate stroke risk.

探讨LVAD植入时VTA消融的效果，观察是否能降低术后VTA的发生率

The primary objective of this trial is to evaluate the safety and efficacy of treatment with anticoagulation alone versus anticoagulation and mechanical aspiration thrombectomy with the Indigo Aspiration System for the treatment of intermediate-high risk acute pulmonary embolism (PE).

The study is being conducted to determine if cenicriviroc mesylate (CVC) will decrease vascular inflammation as measured by 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) imaging of the aorta.

该研究尚未在ClinicalTrials上注册.Gov，这是目前显示详细资格标准的先决条件.

• 如果您需要临床试验方面的帮助.注册肿瘤学研究，请联系 Jonsson综合癌症中心的法规遵从办公室.
• 如果您需要临床试验方面的帮助.非肿瘤学研究的注册，请联系 监管事务办公室.

本研究的主要目的是比较与奥帕西兰治疗的效果, 安慰剂, 对冠心病死亡风险的影响, 心肌梗死, 动脉粥样硬化性心血管疾病(ASCVD)和脂蛋白升高患者的紧急冠状动脉血运重建(a).

COMPLETE-2是前瞻性的, 的多中心, 随机 controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation 心肌梗死 (STEMI) or non-ST-segment elevation 心肌梗死 (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI).

COMPLETE-2 OCT规模较大, 未来的, 的多中心, 观察, STEMI或NSTEMI合并多血管CAD患者在符合条件的COMPLETE-2患者亚群中的影像学研究.

本研究的目的是评价milvexian是否优于安慰剂, 除了标准护理之外, 降低主要心血管不良事件(MACE)(心血管[CV]死亡的组合)的风险, 心肌梗塞[MI], 和缺血性中风).

该研究尚未在ClinicalTrials上注册.Gov，这是目前显示详细资格标准的先决条件.

• 如果您需要临床试验方面的帮助.注册肿瘤学研究，请联系 Jonsson综合癌症中心的法规遵从办公室.
• 如果您需要临床试验方面的帮助.非肿瘤学研究的注册，请联系 监管事务办公室.

The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce 心肌梗死, 缺血性中风, 动脉血管再生, and all-cause death in subjects hospitalized for an acute 心肌梗死 (non-ST-segment elevation 心肌梗死 [NSTEMI] and ST-segment elevation 心肌梗死 [STEMI]).

This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16. 主要假设是Vericiguat在第16周降低NT-proBNP方面优于安慰剂.

该研究的主要目的是评估安全性和耐受性, and pharmacokinetics (PK) of sotatercept over 24 weeks of treatment in children ≥1 to <18 years of age with PAH World Health Organization (WHO) Group 1 on standard of care (SoC). 没有正式的假设.

该研究尚未在ClinicalTrials上注册.Gov，这是目前显示详细资格标准的先决条件.

• 如果您需要临床试验方面的帮助.注册肿瘤学研究，请联系 Jonsson综合癌症中心的法规遵从办公室.
• 如果您需要临床试验方面的帮助.非肿瘤学研究的注册，请联系 监管事务办公室.

这一发现具有创新性, 第一次作用于人体, 前瞻性先导研究将阐明PIMR和RV-IMR在毛细管前PH中的作用. The study cohort will consist of patients with pulmonary pressures ranging from normal (advanced lung disease patients undergoing lung transplant evaluation) to severe PH (PAH and CTEPH patients), 从而可以确定PIMR的截止点. Participants will include: 1) advanced lung disease patients undergoing bilateral heart catheterization as part of their pre-lung transplant work-up, 2)新转诊到PAH和CTEPH诊所接受双侧心导管插入作为标准护理检查的一部分的患者. 所有参与者都将接受PIMR测试, 毛细血管前PH值的患者也将进行肺部OCT和RV-IMR测量. The study seeks to define the relationship between PIMR and PH and to establish the PIMR threshold that identifies pulmonary microvascular dysfunction as well as to evaluate the association of PIMR and pulmonary vascular remodeling on OCT in patients with pre-capillary PH. 除了, 该研究将评估毛细血管前PH患者的RV- imr和RV压力过载之间的关系.

该研究尚未在ClinicalTrials上注册.Gov，这是目前显示详细资格标准的先决条件.

• 如果您需要临床试验方面的帮助.注册肿瘤学研究，请联系 Jonsson综合癌症中心的法规遵从办公室.
• 如果您需要临床试验方面的帮助.非肿瘤学研究的注册，请联系 监管事务办公室.

Patients with end-stage kidney disease (ESKD) who use hemodialysis to filter their blood require vascular access for the dialysis machine; the most common type of vascular access is called an arteriovenous fistula (AVF). AVF是动脉和静脉的直接连接.

直到最近, avf只能通过手术制造，需要全身麻醉和打开皮肤. 现在有两种fda批准的设备设计用于利用血管内技术制造avf (endoAVF), 也就是说，这是一种穿过皮肤而不是打开皮肤的装置. 病人也不需要全身麻醉, 他们可以接受局部麻醉. 由于这些设备的批准相对较新, 目前还没有一项随机研究来比较endoAVF和surgAVF的结果.

这项研究是一项初步研究，最终将进行更大规模的研究，以比较内源性avf和外科avf的结果. 该研究旨在确定寻求血液透析的患者有资格接受内avf的比例 , surgAVF, 或两个. 接受血液透析筛查的患者必须接受手臂血管的双超声检查，以确认正确的大小. If participants qualify f或两个 procedures they will be 随机 to either endoAVF or surgAVF and will track the clinical and patient-reported outcomes of each procedure. 我们的试点研究希望招募90名参与者. 这些结果将为更大规模的研究提供信息. 如果潜在的参与者选择不参加随机试验, 更倾向于决定AVF的创建方法, we will offer to them a chance to join an endoAVF/surgAVF registry that will track the clinical outcomes of the procedure via medical record monitoring.

肺动脉高压(PAH)抵抗的主要调节因子是小动脉. 在心里, 侵入性测量小动脉的阻力已被证明是安全的, 容易, 可靠的, 和预后. This study is intended to translate prior work in heart arteries to the PAH space and invasively measure the resistance of the small arteries of the lung (pulmonary index of microcirculatory resistance [PIMR]) and the coronary artery supplying the right ventricle (acute marginal of the RCA; RV-IMR). 重要的是, these measurements will be made during standard of care cardiac catheterizations (right heart catheterization [RHC] +/- left heart catheterization). The correlation between these new indices and the standard ones measured during RHC typically used to determine the severity of pulmonary hypertension will be analyzed. 除了, 在新确诊患者中, 该研究将评估这些指标在开始治疗6个月后的变化. 最后，将评估这些指标与1年临床结果的关系. The findings from this study may deliver an immediate impact to patient care by identifying a new metric to help better identify those who may benefit from a more intensive, 个性化治疗方案.

This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest.

The study team hypothesizes that longer durations of cooling may improve either the proportion of children that attain a good neurobehavioral recovery or may result in better recovery among the proportion already categorized as having a good outcome.